Xolamol eye drops

Zolamol drops eye active ingredient Dorzolamide with Timolol. What is Zolamol? Because Dorzolamide is a carbonic anhydrase inhibitor in the eye ciliary bodies, resulting in a decrease in aqueous humor secretion in the eye. This may be achieved by reducing bicarbonate ion formation with decreased sodium and fluid conduction. As for Timolol maleate, it is a non-selective adrenergic receptor blocker of beta-1 and beta-2 types and has no sympathomimetic properties, or effects on the heart muscle, or local anesthetic activity. The effectiveness of these two substances together produces an additional reduction in intraocular pressure compared to using each substance separately. What are the uses of Zolamol? Used to treat high intraocular pressure, cases of glaucoma, or false exfoliative glaucoma as an adjunct with other intraocular pressure-lowering medications. What are the contraindications of Zolamol? It is prohibited to use in the following cases: 1- Asthmatic bronchitis or a previous case of bronchial asthma or severe chronic obstructive pulmonary disease. 2- Slow heart rate, second or third-degree atrioventricular block, heart attack, sudden heart failure. 3- Hypersensitivity to any component of the medication. What are the side effects of Zolamol? Potential side effects: Most side effects were mild and did not cause discontinuation. Common local effects include: taste disturbance, burning in the eye, and a stinging sensation. These symptoms have been reported: conjunctival hyperemia, blurred vision, localized corneal ulceration, itching of the eye. Other side effects recorded in a few patients include: abdominal pain, back pain, eyelid inflammation, conjunctivitis, visual disturbances, discharge from the conjunctiva, conjunctival edema, conjunctival vesicle formation, conjunctivitis, corneal ulceration, corneal pigmentation, lens opacity, cough, dizziness, dry eye, indigestion, eye debris, eye discharge, eye pain, eye rupture, eyelid pain or discomfort, foreign body sensation in the eye, glaucoma-related swelling, headache, increased intraocular pressure, conjunctivitis, lens opacity, corneal opacity, pharyngitis, sinusitis, upper respiratory infections, urinary tract infection, vision impairment, vitreous detachment in the eye. What are the precautions for using Zolamol? Pregnancy: There are no sufficient and comprehensive studies on pregnant women, so it is not recommended during pregnancy unless the benefit outweighs the potential risks to the fetus. Breastfeeding: It is unknown if Dorzolamide is excreted in breast milk, so the decision must be made either to stop breastfeeding or to stop taking the medication. Absorption of the preparation may occur. Since Timolol is a beta-receptor blocker, similar side effects as oral beta-blockers may occur even with topical use. Good control of the possibility of heart failure should be maintained before starting treatment with Timolol in this formulation. Symptoms of heart attack and heart rate should be monitored in patients with chronic heart disease. Renal failure: Dorzolamide and its metabolic product are excreted via the kidneys, so it is not recommended for patients with renal failure. Liver failure: Its use has not been studied in patients with liver failure, so it should be used cautiously in these patients. Dorazolamide is a sulfonamide derivative, so side effects associated with sulfonamide use may occur with topical application. Patients using oral beta-receptor inhibitors should be monitored because of the potential for increased effects on intraocular pressure or other side effects of beta-receptor blockade. What are the drug interactions of Zolamol? - When used with calcium channel blockers, catecholamine-depleting drugs, or oral beta-adrenergic receptor blockers, there is a potential for increased effects, decreased blood pressure, or significant slowing of heart rate. - When used with quinidine, increased beta-receptor blockade (such as decreased heart rate) has been recorded, especially because quinidine inhibits the metabolism of Timolol. - Dorzolamide is a topical carbonic anhydrase inhibitor, but it is absorbed. Clinical studies have not recorded Dorzolamide causing disturbances in acid-base balance in the body, but such disturbances have been recorded with oral carbonic anhydrase inhibitors, which in some cases caused drug interactions (such as toxicity related to increased therapeutic salicylate dose). - Oral beta-adrenergic receptor inhibitors may increase hypertension caused by discontinuation of clonidine. What are the storage conditions for Zolamol? Store at temperatures not exceeding 30°C, out of reach of children.