Parsabiv 5 mg Solution for Injection – 6 Vials

Parsabiv 5 mg Solution for Injection – 6 Vials

Parsabiv (Etelcalcetide) is a prescription medicine used to treat secondary hyperparathyroidism in adults with chronic kidney disease receiving hemodialysis.

It belongs to a class of medicines called calcimimetics, which activate calcium-sensing receptors in the parathyroid glands to reduce parathyroid hormone (PTH) secretion.

Reducing elevated PTH helps manage mineral and bone disorders associated with chronic kidney disease as part of a specialist-directed treatment plan.

Active Ingredient

Etelcalcetide, supplied as etelcalcetide hydrochloride.

The verified 5 mg presentation contains 5 mg in 1 mL per vial.

Therapeutic Uses

• Treatment of secondary hyperparathyroidism in adults receiving hemodialysis.
• Reduction of elevated PTH levels.
• Support of mineral metabolism management in chronic kidney disease.

How It Works

Etelcalcetide activates calcium-sensing receptors on parathyroid cells, reducing PTH secretion. Serum calcium levels may also decrease, making regular laboratory monitoring essential.

Dosage and Administration

The usual starting dose is 5 mg intravenously three times weekly at the end of hemodialysis, as prescribed by a specialist.

The maintenance dose is individualized according to PTH and corrected serum calcium levels. The approved maintenance range is generally 2.5–15 mg three times weekly.

Parsabiv must be administered by trained healthcare professionals and is not intended for self-injection.

Monitoring Requirements

Regular monitoring includes corrected serum calcium, PTH and other relevant mineral parameters. Calcium is typically checked within one week of treatment initiation or dose adjustment and periodically during maintenance.

Possible Side Effects

• Low blood calcium.
• Nausea and vomiting.
• Diarrhea.
• Muscle spasms.
• Headache.
• Tingling or numbness.

Severe hypocalcemia may cause seizures, QT prolongation or serious heart rhythm disturbances.

Warnings and Precautions

• Prescription-only medicine.
• For intravenous administration by healthcare professionals.
• Do not initiate treatment when corrected calcium is below the normal range.
• Do not use concurrently with cinacalcet.
• Monitor for hypocalcemia and cardiac complications.
• Not recommended for patients with chronic kidney disease who are not receiving hemodialysis.
• Do not use for self-administration.
• Seek urgent medical assessment for seizures, severe muscle spasms, fainting or palpitations.

Storage

Store refrigerated at 2°C–8°C in the original carton, protected from light. Follow the approved local product instructions for handling outside refrigeration.

Frequently Asked Questions

What is Parsabiv used for?

It treats secondary hyperparathyroidism in adult patients receiving hemodialysis.

Does Parsabiv lower PTH?

Yes. It reduces parathyroid hormone secretion through calcium-sensing receptor activation.

Can Parsabiv lower calcium levels?

Yes. Hypocalcemia is an important treatment risk and requires monitoring.

Can Parsabiv be administered at home?

No. It is administered intravenously by healthcare professionals in connection with hemodialysis.

Is Parsabiv the same as cinacalcet?

Both are calcimimetics, but Parsabiv is intravenous while cinacalcet is oral. They should not be used together.

Does Parsabiv 5 mg contain 2 mL?

No. The verified 5 mg vial contains 1 mL. The 2 mL vial contains 10 mg.

Product Details – Parsabiv 5 mg (6 Vials)

• Brand Name: Parsabiv
• Active Ingredient: Etelcalcetide
• Strength: 5 mg
• Vial Volume: 1 mL for the 5 mg strength
• Pack Size: 6 Vials
• Dosage Form: Solution for Intravenous Injection
• Drug Class: Calcimimetic
• Indication: Secondary Hyperparathyroidism in Adults with Chronic Kidney Disease Receiving Hemodialysis
• Route of Administration: Intravenous, at the End of Hemodialysis
• Dosage: As Prescribed Based on Calcium and PTH Levels
• Manufacturer: Amgen
• Storage: Refrigerate at 2–8°C
• Prescription Status: Prescription Only
• Category: Kidney & Parathyroid Medications