Duphaston 10 mg - 20 tablets

Dydrogesterone 10 mg tablet what is Dydrogesterone and what are its indications: Dydrogesterone is synthetic progestogen and has similar action to female hormone, progesterone. It is used to treat menstrual disorders in women caused by hormone deficiency. It is also used to reduce the risk of miscarriage or abortion. This medication is not recommended for patients under 18 years old. Dydrogesterone is used in the following cases: • Hormone replacement therapy to resist the effects of unopposed estrogen on the endometrium in hormone replacement therapy for women with disorders due to natural or surgical menopause with a healthy uterus. • Progesterone deficiency treatment for progesterone insufficiency such as: • Dysmenorrhea treatment • Endometriosis treatment • Secondary menopause treatment • Irregular cycle treatment • Abnormal uterine bleeding treatment • Premenstrual syndrome treatment • Recurrent and threatened miscarriage associated with confirmed progesterone deficiency treatment • Infertility caused by ovarian insufficiency treatment What you need to know before using Dydrogesterone: Do not use Dydrogesterone: • If you are allergic to Dydrogesterone or any component of this medication • If you know or suspect the presence of progesterone-related tumors (such as meningioma) • If you have unexplained vaginal bleeding • If used to prevent endometrial hyperplasia (in women using estrogen hormone) • If you have lactose intolerance or lactase deficiency or glucose-galactose malabsorption Precautions and warnings: Talk to your doctor before taking Dydrogesterone. • In case of liver dysfunction • In case of previous or current depression • In case of porphyria • In case of unexplained vaginal bleeding Other medications and Dydrogesterone: Inform your doctor if you are taking, have recently taken, or might take any other medications. The metabolism of Dydrogesterone and DHD can be increased by concurrent use of substances known to stimulate CYP enzymes such as: • Anticonvulsants (like phenobarbital, phenytoin, carbamazepine) • Antimicrobials (like rifampicin, rifabutin, nevirapine, efavirenz) • Herbal preparations containing, for example, St. John’s Wort (Hypericum perforatum), ginseng root, sage, or Ginkgo biloba • HIV antivirals (ritonavir and nelfinavir) How to use Dydrogesterone: Dosage: The following dosing regimens are recommended for Dydrogesterone therapy. Dosages can be adjusted according to the severity of the disorder to be treated and individual patient response. Menstrual regulation: It is possible to achieve a 28-day cycle by giving one Dydrogesterone tablet daily from day 11 to day 25 of the cycle. Endometrial: 1 to 3 Dydrogesterone tablets daily from day 5 to day 25 of the cycle or throughout the cycle. The 10 mg doses should be distributed multiple times throughout the day. It is recommended to start treatment with the highest dose. Dysmenorrhea: 1 to 2 Dydrogesterone tablets daily from day 5 to day 25 of the cycle. The 10 mg doses should be distributed multiple times throughout the day. It is recommended to start treatment with the highest dose. Infertility due to corpus luteum insufficiency: One tablet of Dydrogesterone daily from day 14 to day 25 of the cycle. Treatment should continue for at least 6 consecutive cycles. It is advised to continue this treatment during the first months of any pregnancy with doses as specified for habitual abortion. Risk of miscarriage: Starting dose: 4 tablets of Dydrogesterone at once followed by one tablet of Dydrogesterone 10 mg every 8 hours. The 10 mg doses should be distributed multiple times throughout the day. It is recommended to start treatment with the highest dose. If symptoms persist or recur during treatment, increase the dose by one Dydrogesterone tablet every 8 hours. Maintain the effective dose for one week after symptoms stop; then it can be gradually reduced. If symptoms recur, treatment should be resumed immediately at the effective dose. Recurrent abortion: One Dydrogesterone tablet daily until the 20th week of pregnancy; then the dose can be gradually reduced. It is preferable to start treatment before pregnancy. If threatened miscarriage symptoms occur during treatment, treatment should be continued as described for this indication. Irregular uterine bleeding: Stop bleeding by taking two Dydrogesterone tablets daily for 5 to 7 days. Blood loss significantly decreases within a few days. A few days after ending this treatment, withdrawal bleeding occurs sharply, and the patient should be warned about this. Excessive bleeding can be prevented by prescribing a prophylactic dose of one Dydrogesterone tablet daily from day 11 to day 25 of the cycle, if necessary with estrogen for 2 to 3 cycles. After that, treatment can be stopped to ensure the cycle returns to normal. Secondary amenorrhea: 1 or 2 Dydrogesterone tablets daily from day 11 to day 25 of the cycle for optimal endometrial secretion conversion, adequately prepared with internal or external estrogen. Premenstrual syndrome: 10 mg twice daily from day 11 to day 26 of the cycle. Dydrogesterone is not suitable for use before menstruation. The safety and efficacy of Dydrogesterone in adolescents aged 12 to 18 have not been established. Method of administration: Oral use. For higher doses, tablets should be taken in divided doses throughout the day. Possible side effects: Stop using the product and seek medical care immediately if you develop hives, rash, chest tightness, wheezing, or low blood pressure. How to store Dydrogesterone: • Keep this medicine out of sight and reach of children. • Store in a dry place below 30°C. • Protect from light.