Kovram 10 mg / 5 mg - 30 tablets

What is Perindopril / Amlodipine and what is its use: Perindopril is a medicine belonging to a category of drugs known as "ACE inhibitors". Amlodipine belongs to a category of drugs known as "calcium channel blockers". One tablet of this product replaces two separate products of Perindopril and Amlodipine. This combination of active ingredients works by dilating blood vessels, making it easier for your heart to pump blood through them. This medicine is used for the following indications: to treat high blood pressure. To reduce the risk of heart diseases, such as heart attack, in patients with coronary artery disease. Do not take Perindopril / Amlodipine: if you are allergic to Perindopril, or Amlodipine, or any other ingredients of this medicine, or any other ACE inhibitor or calcium channel blocker. if you have previously experienced angioedema caused by Perindopril or another ACE inhibitor. Angioedema is a condition characterized by signs and symptoms such as swelling of the face, throat, or tongue, wheezing, severe itching, or severe rash. if a family member has previously experienced angioedema caused by Perindopril or another ACE inhibitor. if you are taking Bispoprolol / Valsartan (used for heart failure). if you are pregnant or planning pregnancy. if you have diabetes or kidney problems and are taking Aliskiren. if you have renal artery stenosis (narrowing of the artery supplying blood to the kidneys). if you have aortic stenosis (narrowing of the main blood vessels leading to the heart). if you have a severe drop in blood pressure. if you have unstable angina (chest pain or discomfort lasting more than a few minutes or occurring at rest and may not decrease with medication). if you have a heart shock (a sudden and severe decrease in blood flow and blood pressure throughout the body due to weak heart muscle pumping). if you have heart failure (the heart muscle cannot pump blood properly to the body) within the first 28 days after a heart attack. Warnings and precautions: stop taking the medicine immediately and talk to your doctor or pharmacist if you experience allergic reactions such as shortness of breath, rash, facial or neck swelling, low blood pressure, dizziness. Your doctor may recommend reducing alcohol and salt intake, following a healthy diet, exercising, and quitting smoking. Talk to your doctor if you have hypertrophic cardiomyopathy (a heart muscle problem), or aortic stenosis (narrowing of the main arteries leading to the heart), or renal artery stenosis (the artery supplying blood to the kidneys). Talk to your doctor before starting this medicine if you have liver or kidney problems or if you are undergoing dialysis. Talk to your doctor before starting this medicine if you have diabetes. Talk to your doctor before starting this medicine if you have vasculitis (connective tissue disorder) such as scleroderma or systemic lupus erythematosus. Talk to your doctor before starting this medicine if you have high potassium levels or are on a salt-restricted diet or using potassium-containing salt substitutes. Talk to your doctor before starting this medicine if you are going to undergo LDL apheresis (removal of cholesterol from your blood using a machine). Talk to your doctor before starting this medicine if you are going to have surgery and/or anesthesia. Talk to your doctor before starting this medicine if you are going to undergo desensitization therapy to reduce the effects of wasp or bee sting allergy. Talk to your doctor before starting this medicine if you are intolerant to certain sugars. Talk to your doctor before starting this medicine if you have recently experienced vomiting, diarrhea, or dehydration. Talk to your doctor before starting this medicine if you are pregnant or planning pregnancy. Talk to your doctor before starting this medicine if you have primary aldosteronism (abnormally high levels of aldosterone hormone in your blood). Talk to your doctor before starting this medicine if you are undergoing or scheduled for extracorporeal treatments (blood treatments outside your body). Talk to your doctor before starting this medicine if you have heart problems or severe high blood pressure. Do not share your medicine with anyone and do not use it for other purposes. Possible side effects: Rare and serious side effects include signs of allergic reactions such as rash, itching, angioedema (swelling with red skin rash under the skin in a specific part of the body on hands and feet or near them, lips, or eyes), Stevens-Johnson syndrome (a rare and severe skin disease that usually begins with flu-like symptoms followed by a severe and painful rash with blisters), rapid or irregular heartbeat, or difficulty breathing. Common side effects include dizziness, headache, lightheadedness, vision problems, tingling sensations, tinnitus (ringing in the ears), dry and irritating cough, swelling of ankles, feet, hands, or joints, edema (swelling and fluid retention), chest pain, difficulty breathing, dry mouth, nosebleeds, impotence, changes in heart rate or rhythm (fast or irregular), nausea, diarrhea, constipation, indigestion, taste changes, vomiting, abdominal pain, low blood pressure, vasculitis, redness, fatigue, tiredness, lethargy, muscle cramps. Other drugs and Perindopril / Amlodipine: inform your doctor or pharmacist if you are currently taking or have recently taken or might take any other medications including over-the-counter drugs, prescribed medicines, herbal supplements, vitamins, and supplements. If you are taking antihypertensive drugs (such as Aliskiren). If you are taking diuretics (used to increase urination). If you are taking non-steroidal anti-inflammatory drugs (used to reduce inflammation, pain, and fever such as Ibuprofen) or high doses of aspirin. If you are taking medications for diabetes (such as Metformin or Insulin). If you are taking Lithium (used for depression or mania). If you are taking Eplerenone (used for heart failure). If you are taking potassium-sparing medications (such as Spironolactone, Amiloride, Triamterene), potassium-containing salt substitutes, or potassium supplements. If you are taking medications for mental health disorders such as anxiety, depression, or schizophrenia (such as antipsychotics and tricyclic antidepressants). If you are taking Heparin (blood thinner). If you are taking Procainamide (used for arrhythmias). If you are taking Estramustine (used for cancer). If you are taking Allopurinol (used for gout). If you are taking gold salts, especially when administered intravenously (used for rheumatoid arthritis symptoms). If you are taking Trimethoprim (used for infections). If you are taking vasodilators including nitrates (medications to dilate blood vessels). If you are taking medications for asthma, shock, and low blood pressure (such as Ephedrine, Adrenaline, Norepinephrine). If you are taking antibiotics such as Erythromycin, Rifampicin, Clarithromycin. If you are taking antifungals (such as Ketoconazole, Itraconazole). If you are taking Baclofen or Dantrolene (used to treat muscle stiffness in diseases like multiple sclerosis). If you are taking anticonvulsants (used to treat seizures such as Phenytoin, Carbamazepine, Phenobarbital). If you are taking St. John's Wort (used for depression). If you are taking corticosteroids or immunosuppressants (used to reduce the body's defense mechanisms after transplantation or to treat autoimmune disorders like Cyclosporine and Tacrolimus). If you are taking Simvastatin (used to treat high cholesterol). If you are taking Tetracosactide (used for adrenal insufficiency). If you are taking alpha blockers (used to treat prostate enlargement such as Prazosin, Alfuzosin, Tamsulosin, Doxazosin, Terezosin). If you are taking Amifostine (used to prevent or reduce adverse reactions caused by other drugs or radiation therapy used for cancer). If you are taking medications for HIV infection (such as Ritonavir and Indinavir). If you are taking targeted mammalian rapamycin inhibitors (used to prevent organ rejection such as Sirolimus, Temsirolimus). If you are taking Sacubitril / Valsartan (used for long-term heart failure). How to take Perindopril / Amlodipine: Adults The recommended usual dose is one tablet orally once daily. Your doctor will determine the specific dose you need to take. Take exactly as prescribed by your doctor. Consult your doctor or pharmacist if you are unsure. Children This medicine is not recommended for use in children. Elderly The starting recommended dose is 2.5 mg of Perindopril and 2.5 mg of Amlodipine taken as separate tablets in elderly patients. The usual recommended dose is one tablet orally once daily. Do not eat or drink any products containing grapefruit when taking this medicine. Grapefruit may increase the concentration of Amlodipine in your blood, which could lead to excessive lowering of blood pressure. Take the tablet at the same time each day unless otherwise directed by your doctor. Take the tablet before food in the morning. Swallow the tablet with a full glass of water. How to store Perindopril / Amlodipine: Keep the medicine out of reach of children and pets. Store the medicine in a cool, dry place away from light at a temperature below 25°C. Do not store your medicines in the bathroom or near the sink. Do not use the medicine after the expiry date printed on the package. Keep the medicine in its original container to protect it from moisture and light. Do not use damaged tablets. Do not dispose of the medicine in wastewater or household waste.