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Why use Desvenlafaxine: Desvenlafaxine is a selective serotonin and norepinephrine reuptake inhibitor (SNRI), indicated for the treatment of major depressive disorder. How to use Desvenlafaxine: • Recommended dose: 50 mg once daily with or without food. Do not use Desvenlafaxine: • hypersensitivity to desvenlafaxine succinate, venlafaxine hydrochloride, or any excipients. • Do not use it with MAOI or within 14 days of stopping MAOI. Wait 7 days after stopping desvenlafaxine before starting MAOI. Warnings and precautions: • Clinical deterioration / risk of suicide: monitor clinical deterioration and suicide risk. • Serotonin syndrome or neuroleptic malignant syndrome-like reactions (NMS): serotonin syndrome or NMS-like reactions have been reported with selective serotonin reuptake inhibitors and SNRI. discontinue desvenlafaxine and start supportive treatment. • Hypertension: occurred with Desvenlafaxine. Blood pressure control is necessary before starting treatment. monitor blood pressure regularly during treatment. • Unusual bleeding: Desvenlafaxine may increase the risk of bleeding. Patients should be warned about the risk of bleeding associated with concurrent use of Desvenlafaxine and non-steroidal anti-inflammatory drugs or aspirin or other blood-thinning medications. • Angle-closure glaucoma: pupil dilation occurred with Desvenlafaxine. Patients with increased intraocular pressure or at risk of angle-closure glaucoma should be monitored. • Activation of mania / hypomania: occurred. used with caution in patients with bipolar disorder. warn patients of the risk of activating mania / hypomania. • Cardiovascular / cerebrovascular diseases: used with caution in patients with cardiovascular or cerebrovascular diseases. • Elevated cholesterol and triglycerides: already occurred. used with caution in patients with lipid metabolism disorders. consider monitoring blood cholesterol and triglycerides. • Discontinuation symptoms: occurred. reduce dose when possible and monitor withdrawal symptoms. • Renal impairment: reduces desvenlafaxine clearance. dose adjustment is necessary in severe cases and late-stage renal disease. • In moderate renal impairment, the dose should not exceed 50 mg/day. • Seizures: can occur. used with caution in patients with epilepsy. • Hyponatremia: can occur with SIADH. • Drugs containing Desvenlafaxine or Venlafaxine: should not be used concurrently. • Interstitial lung disease and eosinophilic pneumonia: potential side effects. stop using the product and seek immediate medical care if you experience sore throat, swelling of the eyes, face, lips, or tongue, fainting, or difficulty breathing. stop using the product if you experience hives or itching in the face or body. Other drugs Desvenlafaxine: inform your healthcare provider especially if you are taking: • other monoamine oxidase inhibitors • drugs treating migraines known as triptans • tricyclic antidepressants • fentanyl • lithium • tramadol • tryptophan • buspirone • amphetamines • St. John’s Wort • other medications containing Desvenlafaxine or Venlafaxine • blood-thinning medications such as aspirin, NSAIDs, and warfarin • medications used to treat mood, anxiety, psychosis, or thinking disorders, including SSRIs and SNRIs. How to store Desvenlafaxine: Store at 20°C to 25°C. Do not use after the expiration date (EXP) printed on the container. The expiration date indicates the last day of that month. Keep all medicines out of reach of children.